Clinical Trials
Clinical Trials Offer Hope
Clinical trials offer experimental treatments. They try new drugs and new drug combinations, new surgical procedures or devices, or new ways to use existing treatments.There are two types of clinical trials: therapeutic and non-therapeutic. Therapeutic clinical trials enroll patients and provide a specific treatment (surgery, radiation, chemotherapy, immunotherapy, or investigational new drugs) to study its impact on the patient’s cancer. Non-therapeutic trials do not provide treatment to patients. They aim to advance the understanding of cancer through testing tumors or blood, questionnaires and scans.
Finding Out About Clinical Trials
The best place to start is with your medical team. They may already know about a clinical trial that could be a good option for you. They can help search for other possible trials and provide information and guidance as you decide what makes the most sense for you. You can also contact hospitals directly to learn about the clinical trials they are conducting.
Several different websites register clinical trials. Many trials are open at multiple national and even international sites. These databases are updated regularly, but only the doctors conducting the trials have a truly nuanced understanding of their trials and patient eligibility. When searching for a trial, the keyword or term to enter is “SMARCB1”.
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Clinical Trials of Interest
Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors
Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors
Rhabdoid Tumors Cellular Architecture by Single-cell Analyses (InnovRT-2) (InnovRT-2)
Ixazomib, Gemcitabine, and Doxorubicin in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
Induction Chemotherapy and Tazemetostat for Locally Advanced SMARCB1-deficient Sinonasal Carcinoma
Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative
Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS
A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors
FHD-609 in Subjects With Advanced Synovial Sarcoma or Advanced SMARCB1-Loss Tumors
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors
An international prospective umbrella trial for children with atypical teratoid/rhabdoid tumours (ATRT)
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
PRT3789 Monotherapy and in Combo w/Docetaxel in Participants w/Advanced or Metastatic Solid Tumors w/SMARCA4 Mutation
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